糖尿病女性更容易出现性不满

女性糖尿病患者有可能仅仅是感兴趣的，和从事性活动作为非糖尿病女性，但他们更可能报告低总体性满意度，根据UCSF的研究。

研究人员还发现，糖尿病患者接受胰岛素治疗的风险较高，对于润滑性和性高潮的特殊并发症。

“糖尿病是一种公认的危险因素，在男性勃起功能障碍，但几乎没有数据表明它是否也影响女性的性功能，”资深作者艾丽森·黄说，UCSF内科医生和研究人员在UCSF妇女健康临床研究中心。

这项研究是在网上提供的杂志上妇产科。

Huang, lead author Kelli Copeland of the UCSF Women's Health Clinical Research Center, and their colleagues sought to examine the relationship of diabetes to sexual function in an ethnically diverse group of middle-aged and older women。

The disease has the potential to affect sexual function in women through a variety of mechanisms。 These include vascular changes in the urogenital tissues affecting lubrication, and alterations in genital arousal response。 Sexual function also may be adversely affected by diabetes medications or other interventions directed at monitoring or treating the disease, according to the research team。

The researchers sent a questionnaire to 2,270 women aged 40 to 80 years who were insulin-treated diabetic, non-insulin-treated diabetic or non-diabetic women, and then compared their self-reported sexual desire, frequency of sexual activity, overall sexual satisfaction and specific sexual problems (difficulty with lubrication, arousal, orgasm, or pain)。 They also assessed the relationships between diabetic end-organ complications (heart disease, stroke, renal dysfunction and peripheral neuropathy) and sexual function。

Among the 2,270 participants, 486 (21。4 percent) had diabetes。 Of those, 139 (6。1 percent) were taking insulin。 Overall, 63。7 percent of participants reported some sexual activity in the past three months。 The odds of reporting low overall sexual satisfaction were more than two-fold higher in insulin-treated diabetic women, and more than 40 percent higher in non-insulin treated diabetic women, compared to non-diabetic women。

No significant differences in sexual desire or frequency of sexual activity by diabetes status were observed, after the investigators took into account other differences in participants’ demographic background and medical histories。

Among sexually active women, insulin-treated diabetic women were more than twice as likely to report difficulty with lubrication, and 80 percent more likely to report difficulty achieving orgasm compared to non-diabetic women, after adjusting for the same demographic and clinical factors。

Among all diabetic women, end-organ complications such as heart disease, stroke, renal dysfunction and peripheral neuropathy were associated with decreased sexual function in at least one domain。

The study did not examine whether the women had Type 1 or Type 2 diabetes, but the researchers assume that because of age of diagnosis, and when they started insulin, that the majority of participants had Type 2 diabetes。

Previous studies have suggested that psychological factors, such as depression, play a role in sexual dysfunction among diabetic women。 The UCSF team did not assess the impact of depression on female sexual function in this study, but did adjust for antidepressant use among participants since it can worsen sexual function。 The team found that relationships between diabetes and sexual function were independent of anti-depression therapy。

Diabetes is a common chronic condition in the United States。 According to the American Diabetes Association, 12。6 million or 10。8 percent of all women aged 20 years or older have diabetes。

"Based on this research, clinicians may want to consider assessing diabetic women for sexual problems, particularly among those taking insulin, and counsel them that prevention of end-organ complications may be important in preserving sexual function," said Copeland。

The researchers used data from the Reproductive Risks of Incontinence Study at Kaiser 2, comprised of women enrolled in the northern California Kaiser system, in addition to the Northern California Kaiser Permanente Diabetes Registry。

Co-authors are Dr。 Jeanette S。 Brown and Dr。 Leslee L。 Subak, of the UCSF Women's Health Center; Jennifer M。 Creasman, of the UCSF Women's Health Clinical Research Center; Dr。 David H。 Thom of the UCSF Department of Family and Community Medicine; and Stephen K。 Van Den Eeden and Dr。 Assiamira Ferrara of the Division of Research, Kaiser Permanente Northern California, Oakland, Calif。

Funding for the project was provided by the National Institute of Diabetes and Digestive and Kidney Diseases。 Huang also is supported by an award from the National Institute in Aging and the American Federation for Aging Research。 No authors report any potential conflicts of interest related to this research。

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