研究人员说，使用新鲜全血降低了儿童心脏手术中的暴露风险

根据新的研究，在费城儿童医院（砍），接受心脏手术的婴儿和儿童接受新鲜的全血相比，从多个捐助者的血液中接收到的成分血，相比，接受新鲜的全血输注。

“用新鲜全血输血减少个人献血，病人暴露的数量，”该研究的领导者戴维·琼斯，医学博士，在砍在心脏中心心胸麻醉师。“输液反应的风险最为显著与捐赠者，所以限制这样的接触会使患者受益。”公认的风险包括过敏反应、发热、肺损伤和传染病。

琼斯和他的同事将他们的发现发表在5月2015号的胸外科年鉴。

The research team did a retrospective study of 4,111 children receiving heart surgery at CHOP from 1995 to 2010。 Of that number, 3,836 patients received fresh whole blood and 252 received only blood components。 Since 1995, CHOP has provided fresh whole blood in heart surgery patients, relying on components only when whole blood was not available。 Previous experience at CHOP had shown that using whole blood in heart patients reduced blood loss and lowered the need for subsequent transfusions。

In the current study, the median number of exposures was two donors, with higher numbers for younger patients having complex surgeries。 For all the subgroups, the number of exposures was lower than amounts reported in scientific literature for pediatric cardiac patients who received blood components。 The current practice in nearly all pediatric cardiac surgical programs is to rely solely on blood components。

“Many congenital heart conditions necessitate multiple surgeries beginning in infancy, and require multiple transfusions over a patient’s lifetime,” said Jobes, “so limiting donor exposures from the start may reduce long-term complications from blood transfusions。 We hope this research encourages officials to re-examine current blood storage practice and make logistical changes to make whole blood more readily available for pediatric heart patients。”

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