线粒体不仅是细胞的动力装置，这些微小的结构在我们的生理学中也扮演着核心的角色。此外，通过灵活的生理反应，新的环境，线粒体已经帮助人类和其他哺乳动物，以适应和进化在整个地球上的生命的历史。
线粒体生物学先驱科学家，Douglas C。华勒斯博士，综合对线粒体在月24日挑衅性观点文章重要性的证据，在杂志细胞。
Residing in large numbers outside the nucleus of every cell, mitochondria contain their own DNA, with unique features that “may require a reassessment of some of our core assumptions about human genetics and evolutionary theory,” concludes Wallace, director of the Center for Mitochondrial and Epigenomic Medicine at The Children’s Hospital of Philadelphia。
Wallace has investigated mitochondria for more than 40 years。 In 1988, he was the first to show that mutations in mitochondrial DNA (mtDNA) can cause inherited human disease。 His body of research has focused on how mtDNA mutations contribute to both rare and common diseases by disrupting bioenergetics — chemical reactions that generate energy at the cellular level。
Wallace and colleagues previously showed in the late 1970s that human mitochondrial DNA is inherited exclusively through the mother。 They then used this knowledge to reconstruct the ancient migrations of women by comparing variation in mtDNA among populations throughout the world。 From such studies, scientists have concluded that humans arose in Africa about 200,000 years ago and that only two mtDNA lineages successfully left Africa about 65,000 years ago to colonize the rest of the world。
Based on insights from these human migration studies, Wallace takes up a longstanding scientific question raised by Darwinian evolution — both in humans and other species。 As subpopulations moved into isolated areas, how did they remain isolated over a long enough time for new species-defining traits to arise in nuclear genes and become enriched by natural selection to permit speciation?
The vast majority of our 20,000 or so genes exist in the DNA within each cell’s nucleus, as distinct from the 13 protein-coding genes inside mtDNA。 However, Wallace argues that mtDNA mutations provide faster and more flexible adaptations to changing environments than do nuclear DNA mutations。 The mtDNA has a much higher mutation rate than nuclear DNA, which by itself might imperil species survival, because most DNA mutations are deleterious。 However, mtDNA mutations alter physiology at the single-cell level。 Therefore, cells in the mother’s ovary that harbor the most deleterious mtDNA mutations can be eliminated by natural selection prior to fertilization。 Thus only mild mtDNA variants, a subset of which may be potentially beneficial, are introduced into the population。
The high mutation rate in mtDNA plus ovarian selection thus provide a powerful tool for humans (and animals) to adapt to an environmental change, without endangering a population’s overall survival。 Mitochondrial DNA also exchanges signals with nuclear DNA, and the interaction helps drive the evolution of physiological processes over time。 Populations that expand into a marginal environmental space, Wallace argues, adapt their physiology through mtDNA mutation to better exploit the limited food sources and other resources in that environment。 This permits prolonged occupation of the marginal environment, giving sufficient time for nuclear DNA mutations to generate anatomical structures appropriate for exploiting more abundant food resources in the new environment。
To support this hypothesis, Wallace proposes that mitochondria variation can result in crucial energy tradeoffs。 At the cellular level, mitochondria convert oxygen and nutrients to the energy-rich chemical ATP, while also producing heat。 In tropical climates, this coupling process is maximally effective, permitting more efficient production of ATP with minimal heat production。 In the Arctic, the conversion of food to ATP is less efficient, requiring more calories to be consumed for the same amount of ATP, and this generates more heat。 So different patterns of mtDNA variation are likely beneficial in warm versus cold climates。 Similarly, certain mtDNA variants are enriched in Tibetan populations, suggesting that mtDNA variation may permit adaptation to the low oxygen tension at high altitude。
Wallace also cites multiple studies that show that regional mtDNA variation correlates with predilection to a wide variety of metabolic and degenerative diseases, including Alzheimer and Parkinson disease, diabetes, obesity and cardiovascular disease。
Biologists have long known that adaptations that confer an advantage in one environment can become less beneficial in another environment。 Wallace suggests an important contributor to this phenomenon could be the physiological adaptation of mtDNA variation。 He postulates that as populations migrate and dietary patterns become globalized, people with mtDNA optimized to one environment, where they eat a sub-Saharan African diet, may not be well adapted to another environment, where they may consume a Central European diet。 “Because mitochondria have such a crucial role in our physiology, changes in mitochondrial DNA can have profound effects on human biology,” he adds。
The Simon Foundation and the National Institutes of Health (grants NS021328 and CA182384) supported this study。 In addition to his CHOP position, Wallace is on the faculty of the Perelman School of Medicine at the University of Pennsylvania。
“人类辐射和疾病的线粒体基因变异”细胞, Sept。 24, 2015。 http://doi。org/10。1016/j。cell。2015。08。067
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